Consequences of ten comorbidities on the death of ARDS

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It is said that acute Respiratory Distress Syndrome (ARDS) represents 10.4% of all patients admitted to intensive care units (ICUs) and 23.5% of all patients in need of mechanical ventilation. The effects of comorbidities on ARDS mortality are still unknown, although some studies suggest that liver disease, gastrointestinal ulcers, and autoimmune disorders are the leading cause of adverse outcomes in patients with ARDS.



Repeated research on US hospitals that included patients over the age of 18 and those diagnosed with ARDS by the ICD-10 group between 2016 and 2018. The risk factors (non-medical) were high blood pressure, diabetes, obesity. , hypothyroidism, alcohol and drug abuse, kidney disease (CKD), heart disease, liver disease, chronic lung disease and disease.


After removal, 1,046 records were reviewed. Survivors were significantly younger than non-survivors (52.1 vs 62.8; p <0.001) and females (49.1% vs 53.2%; p = 0.004). Hypertension was the most common comorbidity, as well as diabetes and chronic obstructive pulmonary disease. In most studies, it was found that ulcers (OR 2.26, 95% CI 1.84–2.78, p <0.001), heart disease (OR 1.54, 95% CI 1.23–1.92, p <0.001), and CKD (OR 1.75,001) , 95% CI 1.22–2.50, p = 0.002) increased the risk of death. In a combined study, cardiovascular disease combined with gastrointestinal ulcers or CKD provided a significantly higher risk of death compared to the risk alone. Numerous studies have shown serious kidney injury as a major risk factor for ARDS death, but the role of chronic kidney disease has not been well documented.

All illnesses have been shown to increase the frequency of hospitalization after ARDS, and the increase in morbidity increases the number of comorbidities. During the COVID-19 epidemic, age, hypertension, diabetes, obesity and several other diseases were also linked to adverse effects. Among the failures, the recurring nature of the study hinders the founding relationship. In addition, risk factors such as sepsis and aspiration were not considered.

Helpful information

  • ARDS has become one of the most popular ICUs in the world during the COVID-19 epidemic;
  • The disease is most prevalent among hospitalized patients, especially the elderly. Malignancies, heart disease, and kidney disease were associated with high mortality among patients with ARDS.


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# Baig SH, Vaid U, Yoo EJ. The Consequences of Chronic Medical Conditions on Death in Acute Respiratory Distress Syndrome. J Intensive Care Med. 2022 Jun 19: 8850666221108079. doi: 10.1177 / 08850666221108079.

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